Barry Sal (Tom Cruise) seorang pilot pesawat komersil dipindah tugaskan sebagai agen CIA yang menyamar menjadi kurir narkotika untuk raja narkoba, Pablo Escobar.
Sal terus terlibat dalam petualangan yang menegangkan karena harus menjalankan perannya bekerja untuk DEA sekaligus menjadi mata-mata negara dan juga kurir narkoba.
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